Clemson is a heavy favorite on Saturday afternoon in Death Valley.

The Tigers are favored by 13 points, according to the opening line from Circa Sports. The total has been set at 49.5 points.

This is one of the biggest games of the year in the ACC. Both Clemson and Syracuse enter this game with an undefeated record.

The winner will take over as the favorite to win the ACC Atlantic division title. Clemson is looking for its first Atlantic crown since the 2019 season. Syracuse has never won the division.

Clemson is coming off of an impressive road win at Florida State. The Tigers led by double digits for most of that game and ended up with a 34-28 victory in Tallahassee.

Syracuse defeated NC State without Devin Leary this weekend. The Orange, led by quarterback Garrett Shrader and running back Sean Tucker, have been one of the best surprises in college football this season.

Kickoff is at 12 p.m. ET next Saturday afternoon.