Clemson’s top 15 matchup with Syracuse is finally here.

The Tigers and Orange will be fighting for first place in the ACC Atlantic division on Saturday afternoon. Clemson is favored by 2 touchdowns, but Syracuse has played the Tigers close in recent years.

Last season, Clemson escaped the Carrier Dome with a 17-14 win. Three of the last five games in this series have been decided by four points or less.

Here are the picks from the College GameDay crew for Saturday’s contest:

Desmond Howard: Clemson

Pat McAfee: Clemson

Sabrina Ionescu (guest picker): Syracuse

Lee Corso: Clemson

Kirk Herbstreit: Clemson

Both teams are dealing with injuries in this game. Clemson will be without linebacker Barrett Carter, who has started all 7 of the Tigers’ games so far this season. The Orange are expected to be missing star cornerback Garrett Williams, who suffered a leg injury vs. NC State last weekend.

Clemson is 8-2 all-time against Syracuse. The Orange’s only win in this series since joining the ACC came back in 2017 at home. Syracuse has never won in Death Valley.

This game will be broadcast on ABC.