Duke is a 6-point favorite over Louisville on Saturday on the road, according to the latest odds from DraftKings.

This will be the Cardinals’ first game since parting ways with coach Chris Mack after nearly four seasons at the helm. Mike Pegues will serve as Louisville’s interim coach.

The Blue Devils will be looking for their third consecutive win. They defeated Syracuse and Clemson at home last week. Duke hasn’t won on the road since beating Wake Forest on Jan. 12.

Duke will need to take care of business on Saturday if it hopes to continue mounting a résumé worthy of a No. 1 seed in the NCAA Tournament. The Blue Devils are also still within striking distance of first place in the ACC, but can’t afford a third conference loss before the calendar flips to February.

Duke will be led by freshman phenom Paolo Banchero, who is averaging 19.8 points per game over his last five contests. The Blue Devils are 4-1 over that span.

Trevor Keels’ status is unknown for this game. He suffered a lower leg injury against Florida State earlier this month and has missed Duke’s last two games. If he’s unable to go, expect Jeremy Roach to start in his place.

Louisville is the only ACC team that has a winning record over coach Mike Krzyzewski in his career. The Cardinals are 9-7 vs. Krzyzewski all-time.

Tipoff is at 12:00 p.m. ET on Saturday.