Malik Cunningham will not return to Louisville’s game at Clemson.

Cunningham has dealt with multiple injuries this season, and was seen favoring his hand at one point in the first half. But it’s a shoulder ailment that is keeping him from returning vs. the Tigers, per multiple reports.

Brock Domann has entered the game for Louisville. Domann has had an up-and-down season with the Cardinals. He’s played i

n six games and has thrown for 409 yards, one touchdown and two interceptions.

Domann’s last significant run of playing time came in Louisville’s win over Virginia last month. He started that game and threw for 275 yards in the victory.

Louisville has never beaten Clemson. The Cardinals are winless in seven attempts, although several of those games have been decided by just one score.

Louisville entered this game on a four-game winning streak. The Cardinals are already bowl-eligible for the second consecutive season.