Florida State and Louisville are set for a huge conference matchup in Week 3.

According to the opening line from DraftKings, the game has been set as a pick-em.

Louisville started the 2022 season with a tough 31-7 road loss to Syracuse in Week 1 of the 2022 season. Florida State had a wild 24-23 over LSU in Week 1 of the season in New Orleans.

FSU also has a 47-7 win over Duquesne in Week 0 on its résumé. Louisville got its first win of the season with a 20-14 win on the road versus UCF.

Florida State leads the series over Louisville 16-6, but Louisville has won the last two games over Florida State. Louisville defeated Florida State last season 31-23 after the Cardinals jumped to 31-7 lead.

Florida State head coach Mike Norvell is looking to get his first win over Louisville in Week 3.