Notre Dame is a slight betting favorite on the road against Duke in Week 5.

According to the initial line set by Circa Sports, Notre Dame is a 2-point favorite against the Blue Devils in Durham. The total has been set at 52 points.

Here’s the full Week 5 slate of opening lines:

Notre Dame has won 29 consecutive regular season games against ACC opposition. It will look to extend that streak to 30 this week against the Blue Devils.

Notre Dame is coming off of a crushing defeat at home against Ohio State. The Fighting Irish are 4-1, however, and could get back on track with a top-25 win over Duke.

Duke is undefeated this season and put together a dominant performance vs. UConn in Week 4. Quarterback Riley Leonard is one of the better passers in the ACC and Duke also has a good run game to go with its strong defense.

College GameDay will be making its first-ever trip to Duke for this game.

Notre Dame is 5-2 all-time against Duke.